Publications et Recherches du Dr Ahmed Chenna

Highly Sensitive Single Molecular Array Immunoassay Measurement of t-Tau, NF-L, GFAP, and UCH-L1 Biomarkers in Acute Concussion/Mild Traumatic Brain Injury (mTBI) Patient Serum …

A Chenna, C Petropoulos, J Winslow

Neurology 93 (14 Supplement 1), S19-S20

Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients.

U Duvvuri, J George, S Kim, D Alvarado, VM Neumeister, A Chenna, …

Clinical Cancer Research 25 (19), 5752-5758

Highly Sensitive Single Molecular Array Immunoassay Measurement of t-Tau, NF-L, GFAP, and UCH-L1 Biomarkers in Acute Concussion/Mild Traumatic Brain Injury (mTBI) Patient Serum …

A Chenna, C Petropoulos, J Winslow

Neurology 92 (15 Supplement), P2. 9-047

p95HER2–T cell bispecific antibody for breast cancer treatment.

IR Ruiz, R Vicario, B Morancho, CB Morales, EJ Arenas, S Herter, …

IR Ruiz, R Vicario, B Morancho, CB Morales, EJ Arenas, S Herter, …

Master key identification and feedback system.

GL Hagen, M Mueller, M Yeary, KC Booth

US Patent 10,010,949

Molecular and clinical activity of CDX-3379, an anti-ErbB3 monoclonal antibody, in head and neck squamous cell carcinoma: A preoperative” window of opportunity” study.

U Duvvuri, J George, S Kim, D Alvarado, V Neumeister, A Chenna, …

CANCER RESEARCH 78 (13)

Abstract CT058: Molecular and clinical activity of CDX-3379, an anti-ErbB3 monoclonal antibody, in head and neck squamous cell carcinoma: A preoperative” window of opportunity …

U Duvvuri, J George, S Kim, D Alvarado, V Neumeister, A Chenna, …

Cancer Research 78 (13 Supplement), CT058-CT058

Abstract LB-292: p95HER2-T cell bispecific antibody for breast cancer treatment.

R Vicario, IR Ruiz, B Morancho, CB Morales, S Herter, …

Cancer Research 78 (13 Supplement), LB-292-LB-292

p95HER2 methionine 611 carboxy-terminal fragment is predictive of trastuzumab adjuvant treatment benefit in the FinHer trial.

J Sperinde, W Huang, A Vehtari, A Chenna, PL Kellokumpu-Lehtinen, …

Clinical Cancer Research 24 (13), 3046-3052

Elevated TGFa levels in chronic mylogenous leukemia (CML) patient plasma measured by a highly sensitive single molecule array immunoassay.

CJPJWW Ahmed Chenna, Li Cai

Cancer Research 78(13 Supplement):3612-3612 78 (13), 3612-3612

High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance).

ACDEAP Saranya Chumsri, Jeff Sperinde, Heshan Liu, Joseph Gligorov, Jean …

Clinical Cancer Research

Highly sensitive single molecular array immunoassay quantitation of neuronal proteins t-Tau, pTau231, Ab42, and Nf-L in CSF and Alzheimer’s disease plasma.

J Ahmed Chenna, Christos J Petropoulos

Society for Neuroscience 47th Annual Meeting

Adverse health effects of thirdhand smoke: from cell to animal models.

B Hang, P Wang, Y Zhao, A Sarker, A Chenna, Y Xia, AM Snijders, …

International journal of molecular sciences 18 (5), 932

Development of a proximity-based immunoassay to measure the PD1: PD-L1 complex in fixed samples.

G Wallweber, R Ravanera, A Chenna, D Stathas, W Huang, J Winslow, …

Cancer Research 76

Correlation of high p95HER2: HER2 ratio with poor outcome in two phase II clinical trials of trastuzumab-treated HER2-positive metastatic breast cancer.

S Chumsri, J Sperinde, H Liu, J Gligorov, JP Spano, A Moreno-Aspitia, …

Journal of Clinical Oncology 34 (15_suppl), 603-603

Abstract P3-07-09: Quantitative p95HER2 protein expression is predictive of trastuzumab response in HER2-positive metastatic breast cancer.

J Sperinde, B Bachmeier, JM Weidler, Y Lie, A Chenna, J Winslow, …

Cancer Research 76 (4 Supplement), P3-07-09-P3-07-09

Increased expression of HER2, HER3, and HER2: HER3 heterodimers in HPV-positive HNSCC using a novel proximity-based assay: implications for targeted therapies.

NI Pollock, L Wang, G Wallweber, WE Gooding, W Huang, A Chenna, …

Clinical Cancer Research 21 (20), 4597-4606

Prolonged response to trastuzumab in a patient with HER2-nonamplified breast cancer with elevated HER2 dimerization harboring an ERBB2 S310F mutation.

S Chumsri, J Weidler, S Ali, S Balasubramanian, G Wallweber, …

Journal of the National Comprehensive Cancer Network 13 (9), 1066-1070

Development of a sensitive and quantitative PD-L1 immunoassay superior to IHC with application in human FFPE tissue samples.

J Wallweber, A Chenna, R Ravanera, D Stathas, W Huang, C Petropoulos

Cancer Research 75

Association of ErbB/HER Biomarkers with antitumor activity of the anti-ErbB3/HER3 monoclonal antibody KTN3379 in SCCHN.

D Alvarado, J Wallweber, S Seibel, A Chenna, R Ravanera, W Huang, …

AACR Annual Meeting

Correlation of trastuzumab treatment benefit with quantitative HER2 expression levels in HER2 positive metastatic breast cancer.

B Bachmeier, J Sperinde, JM Weidler, Y Lie, A Chenna, J Winslow, …

Journal of Clinical Oncology 33 (15_suppl), 593-593

Abstract P3-06-03: Quantitative p95HER2 and HER2 correlations with outcome in the FinHer trial.

J Sperinde, W Huang, A Vehtari, A Chenna, PL Kellokumpu-Lehtinen, …

J Sperinde, W Huang, A Vehtari, A Chenna, PL Kellokumpu-Lehtinen, …

HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.

WB Growdon, J Groeneweg, V Byron, C DiGloria, DR Borger, …

Gynecologic oncology 137 (1), 160-166

Quantitative HER2 and p95HER2 levels in primary breast cancers and matched brain metastases.

Neuro-Oncology

High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.

M Scaltriti, P Nuciforo, I Bradbury, J Sperinde, D Agbor-Tarh, C Campbell, …

Clinical cancer research 21 (3), 569-576

Smoke: the hidden risks.

B Hang, A Chenna, L Gundel

CHEMISTRY & INDUSTRY 78 (10), 36-36

Quantitative measurements of tumoral p95HER2 protein expression in metastatic breast cancer patients treated with trastuzumab: independent validation of the p95HER2 clinical cutoff.

R Duchnowska, J Sperinde, A Chenna, M Haddad, A Paquet, Y Lie, …

Clinical Cancer Research 20 (10), 2805-2813

NNA, a thirdhand smoke constituent, induces DNA damage in vitro and in human cells.

B Hang, A Iavarone, C Havel, P Jacob III, P Villalta, B Matter, D Sharan, …

Abstracts of Papers of the American Chemical Society 247.

Abstract P6-11-07: Quantitative p95HER2 levels in primary breast cancers and in matched brain metastases.

R Duchnowska, J Sperinde, A Chenna, W Huang, J Weidler, J Winslow, …

Cancer Research 73 (24 Supplement), P6-11-07-P6-11-07

HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer.

A Lipton, L Goodman, K Leitzel, J Cook, J Sperinde, M Haddad, …

Breast cancer research and treatment 141 (1), 43-53

Quantitative measurements of p95HER2 (p95) protein expression in tumors from patients with metastatic breast cancer (MBC) treated with trastuzumab: Independent confirmation of …

R Duchnowska, J Sperinde, M Haddad, A Chenna, A Paquet, Y Lie, …

Journal of Clinical Oncology 31 (15_suppl), 604-604

Profiling HER3/ErbB3 activation in formalin-fixed, paraffin-embedded (FFPE) breast tumor samples that express high and low HER2/ErbB2 levels using proximity-based immunoassays.

J Wallweber, A Chenna, R Ravanera, W Huang, D Stathas, G Marshall, …

Cancer Research 73 (8 Supplement), 3029-3029

Thirdhand smoke causes DNA damage in human cells.

B Hang, AH Sarker, C Havel, S Saha, TK Hazra, S Schick, P Jacob III, …

Mutagenesis 28 (4), 381-391

Enhanced method for detecting and/or quantifying an analyte in a sample.

Y Badal, A Chenna, SH Tahir, Y Tan

US Patent 8,357,277

Correlation of quantitative p95HER2, HER2, and HER3 protein expression with pathologic complete response (pCR) in HER2-positive breast cancer patients (pts) treated with …

JC Villasboas, J Hurley, JM Weidler, A Paquet, CG Fernandez, …

Journal of Clinical Oncology 30 (27_suppl), 137-137

A comparative study of p95-HER2 carboxy terminal fragment (CTF) detected by immunohistochemistry and VeraTag assays in human breast tumors.

J Sperinde, A Chenna, J Zhang, V McWhorter, L Dierbeck, M Da Silva, …

Cancer Research 72 (8 Supplement), 687-687

A comparative study of p95-HER2 carboxy terminal fragment (CTF) detected by immunohistochemistry and VeraTag immunoassays in human breast tumors.

J Sperinde, A Chenna, J Zhang, V McWhorter, L Dierbeck, M Da Silva, …

American Association for Cancer Research (AACR) Annual Meeting, Mar

Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins.

A Mukherjee, Y Badal, XT Nguyen, J Miller, A Chenna, H Tahir, A Newton, …

PLoS One 6 (1), e16443

Benzene-derived N2-(4-hydroxyphenyl)-deoxyguanosine adduct: UvrABC incision and its conformation in DNA.

B Rodriguez, Y Yang, AB Guliaev, A Chenna, B Hang

Toxicology letters 193 (1), 26-32

A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed …

Y Shi, W Huang, Y Tan, X Jin, R Dua, E Penuel, A Mukherjee, J Sperinde, …

Diagnostic Molecular Pathology 18 (1), 11-21

Synthesis of the Fully Protected Phosphoramidite of the Benzene-DNA Adduct, N 2-(4-Hydroxyphenyl)-2′-Deoxyguanosine and Incorporation of the Later into DNA Oligomers.

A Chenna, RC Gupta, RR Bonala, F Johnson, B Hang

Nucleosides, Nucleotides and Nucleic Acids 27 (8), 979-991

Characterization of a novel proximity immunoassay for the quantitative determination of HER2 protein expression and HER2 homodimerization in formalin-fixed, paraffin-embedded …

J Winslow, Y Shi, Y Tan, X Jin, R Dua, E Penuel, A Mukherjee, J Sperinde, …

Breast Cancer Research and Treatment 106 (1 Suppl), S88

Detection of nucleic acid sequences by cleavage and separation of tag-containing structures.

A Chenna, V Xiao, S Singh

US Patent App. 11/447,753

The ERB family receptor dimerization in glioblastoma—An eTag assay analysis of 23 cases.

MR Hameed, L Sharer, E Cho, S Aisner, L Cao, Y Tan, A Mukherjee, …

Journal of Clinical Oncology 24 (18_suppl), 1582-1582

Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents.

A Chenna, S Singh

US Patent 7,037,654

Kits employing generalized target-binding e-tag probes.

S Singh, T Matray, A Chenna

US Patent 7,001,725

ErbB/HER pathway profiling in formalin-fixed paraffin embedded preclinical xenograft models using multiplexed proximity-based assays.

R Dua, Y Shi, L Cao, A Mukherjee, Y Tan, H Pannu, J Pannu, L Jarvis, …

International Conference on Molecular Targets and Cancer Therapeutics, AACR …

Kits employing oligonucleotide-binding e-tag probes.

S Singh, T Matray, A Chenna

US Patent 6,955,874

Sets of oligonucleotide-binding e-tag probes.

S Singh, T Matray, A Chenna

US Patent 6,916,612

Correlation of ErbB activation status and clinical response in Herceptin treated breast cancer patients.

A Mukherjee, J Pannu, L Cao, S Gangakhedkar, Y Tan, R Dua, H Tahir, …

Cancer Research 65 (9 Supplement), 869-870

Multiplexed assay for assessing ErbB/HER receptor pathways in formalin-fixed and paraffin-embedded cancer cell lines.

Y Shi, R Dua, A Mukherjee, L Cao, Y Tan, L Jarvis, H Pannu, TN Nguyen, …

Cancer Research 65 (9 Supplement), 1354-1354

Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents.

A Chenna, S Singh

US Patent App. 10/494,879

Multiplexed analysis by chromatographic separation of molecular tags.

A Chenna, T Matray, V Hernandez, H Hooper, S Singh

US Patent App. 10/918,876

Sets of generalized target-binding e-tag probes.

S Singh, T Matray, A Chenna

US Patent App. 10/779,255

Sets of generalized target-binding e-tag probes.

S Singh, T Matray, A Chenna

US Patent 6,770,439

Erratum to”Miscoding properties of 1, N 6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1, 3-bis (2-chloroethyl)-1-nitrosourea”-[Mut. Res. 531 …

B Hang, A Chenna, AB Guliaev, B Singer

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 1 (546 …

Multiplex mRNA assay using electrophoretic tags for high-throughput gene expression analysis.

H Tian, L Cao, Y Tan, S Williams, L Chen, T Matray, A Chenna, S Moore, …

Nucleic acids research 32 (16), e126-e126

Methods for detecting a plurality of analytes by mass spectrometry.

TJ Matray, VS Hernandez, A Chenna, H Hooper, S Singh

US Patent 6,649,351

Monooxygenase assays.

S Singh, A Chenna, H Salimi-Moosavi, I Gibbons

US Patent App. 10/465,475

Miscoding properties of 1, N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1, 3-bis (2-chloroethyl)-1-nitrosourea.

B Hang, A Chenna, AB Guliaev, B Singer

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 531 (1 …

Monooxygenase assays.

S Singh, A Chenna, H Salimi-Moosari, I Gibbons

US Patent 6,632,630

Miscoding properties of 1, N-ethanoadenine, a DNA adduct derivedfrom reaction with the antitumor agent 1, 3-bis (2-chloroethyl)-1-nitrosourea.

B Hang, AB Guliaev, A Chenna, B Singer

Simultaneous multiplexed toxicogenomic and toxicoproteomic profiling.

S Singh, D Tabor, T Tian, L Chen, L Cao, S Williams, T Matray, A Chenna, …

TOXICOLOGICAL SCIENCES 72, 98-98

Synthesis of 8-(Hydroxymethyl)-3,N4-etheno-2‘-deoxycytidine, a Potential Carcinogenic Glycidaldehyde Adduct, and Its Site-Specific Incorporation into DNA …

A Chenna, A Perry, B Singer

Chemical research in toxicology 13 (3), 208-213

Synthesis of para-benzoquinone and 1, 3-bis (2-chloroethyl) nitrosourea adducts and their incorporation into oligonucleotides.

A Chenna, H Maruenda, B Singer

IARC scientific publications, 89-101

Differential cleavage of oligonucleotides containing the benzene-derived adduct, 1, N6-benzetheno-dA, by the major human AP endonuclease HAP1 and Escherichia coli exonuclease …

B Hang, A Chenna, J Sagi, B Singer

Carcinogenesis 19 (8), 1339-1343

Synthesis of 1,N6-Ethano-2‘-deoxyadenosine, a Metabolic Product of 1,3-Bis(2-chloroethyl)nitrosourea, and Its Incorporation into Oligomeric DNA.

H Maruenda, A Chenna, LK Liem, B Singer

The Journal of Organic Chemistry 63 (13), 4385-4389

A single cyclic p-benzoquinone adduct can destabilize a DNA oligonucleotide duplex.

J Sagi, A Chenna, B Hang, B Singer

Chemical research in toxicology 11 (4), 329-334

Sequence context is an important determinant in the mutagenic potential of 1, N6-ethenodeoxyadenosine (epsilonA): formation of epsilonA basepairs and elongation in defined …

V Litinski, A Chenna, J Sagi, B Singer

Carcinogenesis 18 (8), 1609-1615

Synthesis of a Benzene Metabolite Adduct, 3‘‘-Hydroxy-1,N2-benzetheno-2‘-deoxyguanosine, and Its Site-Specific Incorporation into DNA Oligonucleotides.

A Chenna, B Singer

Chemical research in toxicology 10 (2), 165-171

An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of …

B Hang, A Chenna, H Fraenkel-Conrat, B Singer

Proceedings of the National Academy of Sciences 93 (24), 13737-13741

Replication of O4-methylthymine-containing oligonucleotides: Effect of 3′ and 5′ flanking bases on formation and extension of O4-methylthymine· guanine basepairs.

S Rao, A Chenna, M Slupska, B Singer

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 356 (2 …

Enzymological repair of exocyclic DNA adducts formed by environmental carcinogens.

B Singer, B Hang, A Chenna

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 212, 70-TOXI

1, N6-Ethenoadenine and 3, N4-ethenocytosine are excised by separate human DNA glycosylases.

B Hang, A Chenna, S Rao, B Singer

Carcinogenesis 17 (1), 155-157

Large Scale Synthesis of p-Benzoquinone-2′-Deoxycytidine and p-Benzoquinone-2′-Deoxyadenosine Adducts and Their Site-Specific Incorporation into DNA Oligodeoxyribonucleotides.

A Chenna, B Singer

Chemical research in toxicology 8 (6), 865-874

The benzene metabolite p-benzoquinone forms adducts with DNA bases that are excised by a repair activity from human cells that differs from an ethenoadenine glycosylase.

A Chenna, B Hang, B Rydberg, E Kim, K Pongracz, WJ Bodell, B Singer

Proceedings of the National Academy of Sciences 92 (13), 5890-5894

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

MK Dosanjh, A Chenna, E Kim, H Fraenkel-Conrat, L Samson, B Singer

Proceedings of the National Academy of Sciences 91 (3), 1024-1028

Characterization of 2′-deoxycytidine and 2′-deoxyuridine adducts formed in reactions with acrolein and 2-bromoacrolein.

A Chenna, CR Iden

Chemical research in toxicology 6 (3), 261-268

Characterization of thymidine adducts formed by acrolein and 2-bromoacrolein.

A Chenna, RA Rieger, CR Iden

Carcinogenesis 13 (12), 2361-2365

Functionalized Benzocyclo-octenones: Synthesis and Chemistry.

GRPJR Ahmed Chenna, John Donnelly, Kevin J. McCullough

Journal of the Chemical Society, Perkin Transactions 1, 261-270

Aspects of the chemistry of some benzocyclo-octanes.

A Chenna

University of Strathclyde

1, 3-bis (2-chloroethyl) nitrosourea adducts and their incorporation into.

A Chenna, H Maruenda, B Singer

High HER2 Expression Correlates with Response to the Combination of Lapatinib and Trastuzumab.

PG Nuciforo, V Serra, L Prudkin, J Cortes